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Vitamin D for Perinatal Depression

BabyResearchers wishing to study the effect of vitamin D3 supplementation on prenatal depression scores conducted a randomized clinical trial on pregnant women under prenatal care. Participants were 18 years of age or older with a gestational age of 26-28 weeks, no history of mental illness and no pregnancy complications. Participants had a depression score of 0-13 using the Edinburg Postnatal Depression scale for evaluation of depression scores. 169 participants were randomized to the placebo group or the supplemented group receiving 2,000 IU of vitamin D3 daily from 26-28 weeks of gestation until child birth. Maternal serum 25-hydroxyvitamin D concentrations were measured at baseline and childbirth. Additionally, depression scores were evaluated at weeks 26-28 and 38-40 weeks of gestation, as well as at 4 and 8 weeks after birth. There was no significant difference between the two study groups at baseline. However, there was significant reduction in depression scores in the supplemented group compared to placebo at 38-40 weeks of gestation, and at 4 and 8 weeks after birth. Researchers concluded that 2,000 IU of vitamin D3 per day for at least 8 weeks during late pregnancy, can be effective in decreasing perinatal depression levels.

Vaziri et al. BMC Pregnancy and Childbirth (2016) 16:239 doi 10.1186/s12884-016-1024-7

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