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Vitamin D for Statin Induced Myalgia

vitamin-D-1Research has demonstrated that low serum vitamin D can cause myalgia, myositis, myopathy, and myonecrosis. Statin-induced myalgia is a major and common cause of statin intolerance. In a study of 146 adults with myalgia related statin intolerance found to have low (<32 ng/mL) serum vitamin D, researchers prospectively assessed whether vitamin D supplementation  to normalize serum vitamin D would allow successful re-challenge therapy with statins. Median serum vitamin D levels at entry in the 24 month study was 22-23 ng/mL, and rose at 6, 12, and 24  months to 53-55 ng/mL, normalizing in 95% of patients after 24 months following vitamin D therapy. On the 6, 12 and 24 month follow-up on re-challenged patients on statins and vitamin D, 88%, 91% and 95% of the previously statin-intolerant patients, respectively, were free of myalgia, myositis, myopathy, and/or myonecrosis! Before beginning the study, all the patients had experience myalgia, myositis, myopathy, or myonecrosis on statins (predominantly simvastatin, atorvastatin or lovastatin). This current study supports the findings of three previous studies associating statin related myalgias with low serum vitamin D status. By providing supplemental vitamin D to statin-intolerant patients with low serum vitamin D at entry, 88% were subsequently able to tolerate re-challenge with stains with excellent tolerability, and the LDLC lowering to targeted levels. Researchers concluded that statin intolerance because of myalgia, myositis, myopathy, or myonecrosis in vitamin D deficient patients can, in most cases (88%-95%)be safely resolved by vitamin D supplementation!

Khayznikov M, et al. Statin Intolerance Because of Myalgia, Myositis, Myopathy, or Myonecrosis Can in Most Cases be Safely Resolved by Vitamin D supplementation. N Am J Med Sci. 2015 Mar; 7(3): 86-93.

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