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The Health Benefits of Intermittent Fasting

Food_clockIntermittent fasting appears to calm inflammation and rescue cognitive function in animals’ brains. The action is associated with “knocking down the quantity of proinflammatory cytokines, elevating levels of brain-derived neurotrophic factor (BDNF), and activating the transcription factor known as NF-κB, which is involved in adaptive stress responses. In addition, BDNF activates PGC-1α, which functions in the regulation of the production of new mitochondria, dendritic spines, and synapses in the hippocampus. Fasting that involves longer periods of food deprivation has been demonstrated to result in changes to the immune system and the hematopoietic stem cells that support it. The director of USC’s Longevity Institute, Longo has studied periodic fasting, less frequent but longer bouts of severe calorie restriction. He has found that the routine can reshape immune cell populations in the body. Most studies utilize the fasting-mimicking diet (FMD). Using a periodic three-day FMD regimen for 30 days in a mouse model of multiple sclerosis, Longo and colleagues showed that the fast-and-feed cycles pruned away populations of autoimmune T cells, replacing them with immune cells that were no longer set on attacking neural tissue. Much of the basic biological work on fasting diets has been performed in animal models of disease. These models demonstrated improvements in or protection against symptoms of diseases such as Alzheimer’s, multiple sclerosis, cardiovascular disease, diabetes, and other metabolic disorders.

 

Grant B. Running on Empty. The Scientist June 1, 2017. http://www.the-scientist.com/?articles.view/articleNo/49462/title/Runnin....

 

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