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More Bad News on PPI Use and Chronic Kidney Disease

In a population-based Taiwanese study of those taking proton pump inhibitors (PPIs), the long-term safety of PPI-associated chronic kidney disease (CKD) and kidney injury was evaluated, as it is viewed as a significant concern in these patients. The use of PPIs predisposed these individuals to a 1.4-fold higher odds of CKD, as compared to those who never used PPIs. The study also recognized that “almost all major types of PPIs present a weak association with increased odds of CKD in cumulative duration and dosage regression analysis.” Thus, according to this evaluation, the use of proton pumpinhibitors correlated with an increased risk of chronic kidney disease, as an elevated risk of acute kidney injury was demonstrated in these individuals. [“The OR for CKD was 1.41 for subjects using PPIs [95% confidence interval (CI) 1.34, 1.48] compared with subjects who had never used PPIs. The OR in relation to cumulative duration (per month) of PPIs use was 1.02 (95% CI 1.01, 1.02) and the OR in relation to cumulative dosage (per microgram) of PPIs use was 1.23 (95% CI 1.18, 1.28).”]

Hung S-C, Liao K-F, Hung H-C, Lin C-L, Lai S-W, Lee P-C, Hung S-R. Using proton pump inhibitors correlates with an increased risk of chronic kidney disease: a
nationwide database-derived case-controlled study. Family Practice. 14 October 2017 cmx102, https://doi.org/10.1093/fampra/cmx102.

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