INTRODUCING

Sleep & Stress Peptides

BY BIOTICS RESEARCH®

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SLEEP & STRESS PEPTIDES

Bioactive peptides.
Targeted solutions.

Clinically studied bioactive peptides for the sleep-stress cycle.

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SleepTides

Targets sleep architecture

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De-Stress Peptides

Targets stress resilience

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SleepTides Synergy

Combines both into one
comprehensive formula

THE PROBLEM

Stress & sleep are locked in a cycle.
One fuels the other.

50-70 million Americans experience inadequate sleep. For many, the root cause isn't just sleep itself — it's unresolved stress that disrupts the body's natural ability to fall asleep, stay asleep, and wake feeling restored. Traditional approaches address one side or the other. Our Sleep & Stress Peptides platform addresses both.

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50 - 70

Million

Americans experience inadequate sleep

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2X

People with high stress are 2x more likely to have poor sleep

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43%

Report lying awake at night due to stress

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77%

Say stress impacts their sleep quality

THE COMPLETE SLEEP & STRESS FORMULA

SleepTides Synergy

Fall asleep. Stay asleep. Wake restored. Stay calm all day.

OREXIN-CORTISOL PATHWAY

PeptiSleep
250 mg

Modulates the orexin pathway and supports healthy cortisol rhythm for restorative sleep architecture.

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GABA-A
PATHWAY

Lactium®
250 mg

Selectively supports GABA-A receptor activity for calm, balanced stress response without sedation.

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HEART RATE
VARIABILITY

HRV is an indicator of how well your body can adapt to its environment and perform

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REM SLEEP

REM is important for
memory, learning,
and emotions

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DEEP SLEEP

Deep sleep is important for physical recovery and immune system strengthening

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TOTAL SLEEP

On average

Source: Sleepfoundationorg: Effects of PeptiSleep in Healthy Males and Females with Mild to Moderate Sleep Impairment (manuscript under preparation)
*Significant result (p ≤ 005) ^Not statistically significant, but clinically meaningful difference

Two clinically studied peptides.
One formula.

Dual-pathway support for sleep onset, sleep architecture, and stress resilience.

Supports healthy sleep onset and
sleep maintenance*
Supports a calm, balanced stress
response*
Promotes deeper, more restorative
sleep phases*
Non-habit forming — works with your
body's own biology

The Building Blocks

SleepTides

Bioactive Peptides for
Restorative Sleep

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purple-moonThe Sleep Architecture Specialist

SleepTides features a patented brown rice protein hydrolysate (PeptiSleep, 250 mg) containing a unique network of bioactive peptides. It modulates the orexin pathway and supports healthy cortisol rhythm — addressing the root hysiological drivers of sleep disruption rather than simply inducing drowsiness.

Icon - CheckBest for:

  • Patients with mild-to-moderate sleep disturbances or night wake-ups
  • Those who don't feel restored after a full night's sleep
  • Patients who use sleep support but wake up feeling groggy

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  • 100% plant-based, vegan, non-GMO
  • Non-habit forming
  • Supports all phases of the sleep cycle

Clinical Evidence:
LEEDS Questionnaire

250 mg 30 Minutes Before Bed

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Ease of getting to sleep
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Perceived quality of sleep
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Ease of awakening from sleep
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Behavior following wakefulness

Source: Nuritas Effects of PeptiSIeep in Healthy Males and Females with Mild to Moderate Sleep Impairment (manuscript under preparation)
*Significant result (p ≤ 0.05)

DeStress Peptides

A Different Kind of Calm

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Group 6-2The Stress Resilience Specialist

De-Stress Peptides features Lactium® (150 mg) — a patented bovine milk casein hydrolysate containing the bioactive decapeptide alpha casozepine. It selectively supports GABA-A receptor activity in the brain, promoting a calm, balanced stress response without the sedation or dependency associated with pharmaceutical options.

Icon - Check copyBest for:

  • Patients experiencing everyday stress and its physical symptoms
  • Those seeking natural stress support without Rx side effects
  • Patients whose sleep is disrupted by stress-related arousal

Icon - Star copyKey Differentiators

  • Non-habit forming — no sedation, no dependency
  • 9+ clinical studies across 800+ participants in multiple countries
  • Benefits often felt within days to weeks
  • Food-derived — from a calming pool of milk-derived peptides

Clinical Evidence: Stress Metrics

150 mg/day for 30 days

Digestive

0%

Cardiovascular

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Intellectual

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Emotional

0%

Social

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Kim et al., Eur J Clin Nutr, 2007;61(4):536-41

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reduction in plasma cortisol

Messaoudi et al., Eur J Nutr, 2005;44(2):128-32

WHY BOTH PATHWAYS MATTER

Sleep & stress aren't two problems.
They're one cycle.

Orexin drives wakefulness and cortisol. When overactive in the evening, patients can't fall asleep or stay asleep. PeptiSleep modulates this pathway.

GABA-A is the brain's primary calming system. When stress overwhelms GABA tone, the result is racing thoughts and stress-related arousal. Lactium® supports this system.

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OREXIN/CORTISOL PATHWAY

(PeptiSleep)

  • Reduces orexin activity*
  • Supports healthy cortisol rhythm*
  • Promotes sleep onset*
  • Improves sleep architecture*

SLEEPTIDES SYNERGY

Complete Sleep-Stress Cycle Support

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GABA-A PATHWAY

(Lactium®)

  • Enhances GABA-A activity*
  • Promotes calm, balanced stress response*
  • Reduces stress-related arousal*
  • Supports daytime resilience*

Only SleepTides Synergy Targets Both Pathways

Which product is right for your patient?

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SleepTides

Sleep support peptides

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SleepTides Synergy

Dual-Pathway
Sleep-Stress Support

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DeStress Peptides

Stress & Sleep Support

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