Resveratrol (3, 4, 5-trihydroxystilbene), a natural polyphenolic phytoalexin found in grapes, as well as other botanicals such as knotweed. Interest has arisen due to its cardioprotective action on the vasculature, particularly its ability to inhibit formation of new blood vessels, and to facilitate vasorelaxation. However, recent evidence has noted that it may also be beneficial for eye support. In this study resveratrol and its three metabolites was detected in the ocular tissues following oral administration. Although detected at low concentrations, there is some speculation that resveratrol and its metabolites could play a role in the treatment of ocular diseases. Additionally, along with quercetin, and catechins, resveratrol was demonstrated to significantly reduce cell proliferation and to block cell cycle progression in vitro. The main quantitative substances in the aqueous and vitreous humor were noted to be the hydrophilic substances of resveratrol metabolites. Resveratrol and its metabolites were noted to be higher in the conjunctiva. Other studies have demonstrated that resveratrol is beneficial to the human eyes.
Wang S, Wang Z, Yang S, Yin T, Zhang Y, Qin Y, Weinreb RN, Sun X. Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes. J of Ophthalmology, 2017, Article ID 4052094, 12 pages, 2017. doi:10.1155/2017/4052094.