In order to further investigate “the association between serum bicarbonate and the risk of progressing to impaired fasting glucose (IFG)/diabetes mellitus (DM),” Li S, Wang Y-Y, et al. studied 5318 participants aged 18–70 years, with no history of diabetes or concomitant chronic disease, over a period of 6 years.
Of these participants, 210 participants developed IFG after a median 2.2 years of follow-up. “After adjusting for multiple factors, including sex, age, fasting plasma glucose (FPG), and body mass index at baseline, the participants in the first (OR 4.18, 95% CI 2.42 to 7.21; p<0.001), second (OR 3.02, 95% CI 1.71 to 5.33; p<0.001) and third (OR 2.12, 95% CI 1.15 to 3.89; p=0.015) quartiles of serum bicarbonate had higher odds for progressing to IFG/DM compared with those in the highest quartile.”
Thus, they concluded that a lower serum bicarbonate is, in fact, associated with a higher risk of developing IFG/DM, which also corroborated the results of a previous study from 2012 showing high-serum bicarbonate is associated with low risk of progression to T2DM in women.
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