New Paper Reveals Three Finite Vascular Responses that Cause Cardiovascular Disease

New research by Mark C. Houston, MD, MS, MSc, FACP, FAHA, FASH, FACN, FAARM, DABC, Director of the Hypertension Institute and Vascular Biology, provided a comprehensive, logical and in-depth approach to the treatment of heart disease. He stated “Approximately 80% of coronary heart disease (CHD) can be prevented by optimal nutrition, optimal exercise, optimal weight and body fat, mild alcohol intake, and avoiding smoking”.  Houston calls these preventable reasons for coronary heart disease (CHD) “external insults” to the cardiovascular (CV) system. According to Houston, the underlying root cause for CHD is the overwhelming external insults to the CV system. The study revealed three clear finite responses to these external insults, which are vascular inflammation, vascular oxidative stress and vascular immune dysfunction.

Coronary heart disease and cardiovascular disease continue to be the leading causes for death in the US. New understanding, evaluation, prevention, and treatment strategies are required to allow for early identification, prevention and treatment of coronary heart disease and cardiovascular disease. This new paper presents strong evidence on approaches for revolutionizing the treatment of CHD.

Endothelial cell membranes are the primary line of defense to the external insults that lead to the pathophysiology of CHD. The ability for a cell to protect itself efficiently varies depending on the biological fatty acid makeup of the cell membrane with trans fats (TFA), saturated fats (SFA), monounsaturated fats (MUFA), or omega-3 fats (PUFA). Chronic insults to the cell membrane can result in vascular inflammatory, oxidative stress, and immune responses. The result is that the CV system can become deregulated and dysfunctional, damaging the CV system.

Houston outlined a wide range of top modifiable coronary heart disease risk factors (a brief summary of the 395 new and emerging risk factors) including vitamin and mineral deficiencies, lack of sleep, lack of exercise and stress. What's more, other interventions were discussed such as the "Portfolio Diet" that resulted in a reduction of low-density lipoprotein cholesterol (LDL-C) of 13.1%.

Houston concluded that revolutionizing the treatment of CHD, requires a new approach that “must address the underlying pathophysiology, CHD risk factors, mediators, and their downstream effects, as well as the three finite vascular responses. This will be achievable by using a combination of targeted personalized and precision treatments with genomics, proteomics, metabolomics, nutrition, nutraceutical supplements, vitamins, minerals, antioxidants, anti-inflammatory agents, anti-immunological agents and drugs.”

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