---
title: "Review: The Role of Vitamin D and Lipoprotein Receptor-Related Protein in Amyloid Clearance and Brain Health"
description: A review on the relationship between vitamin D and lo-density lipoprotein receptor-related protein (LRP-1) has revealed that the two may work together to possibly clear amyloid-beta (Aβ), whose deposition is considered linked to the progression of neurological dysfunction.
---

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# [Review: The Role of Vitamin D and Lipoprotein Receptor-Related Protein in Amyloid Clearance and Brain Health](https://info.bioticsresearch.com/researchforum/review-the-role-of-vitamin-d-and-lipoprotein-receptor-related-protein-in-amyloid-clearance-and-brain-health)

 Written by [The Biotics Research Team](https://info.bioticsresearch.com/researchforum/author/the-biotics-research-team) | Apr 18, 2019 12:54:41 PM

A review on the relationship between vitamin D and low-density lipoprotein receptor-related protein (LRP-1) has revealed that the two may work together to possibly clear amyloid-beta (Aβ), whose deposition is considered linked to the progression of neurological dysfunction.

LRP-1 is a large receptor present on the body’s cells and is [widely expressed, or present, in several tissues](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744109/). It’s a member of the LDL receptor family, which plays various different roles related to [enzyme activation, the entry of bacterial toxins and viruses into cells, and the metabolism of proteins that transport and combine with fats in the blood](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744109/).

But LRP-1 has also been identified as a Aβ scavenger receptor that can remove Aβ from the brain through the blood-brain barrier. However, its expression is decreased in patients with neurological dysfunction.

This review points to recent evidence that after supplementation with [the active form of vitamin D, 1,25-(OH)2D3](https://www.ncbi.nlm.nih.gov/pubmed/15585793), LRP1 expression increases significantly both in-vivo and in-vitro. This is because so many vitamin D receptors are expressed in the brain.

Several studies also suggest that vitamin D receptor (VDR, the receptor to which vitamin D binds to in the body) deficiency, or inhibition, could be a risk factor for neurodegenerative disease. This review establishes a strong connection between vitamin D, LRP-1, and their potential Aβ clearance abilities.

 

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