---
title: Vitamin K2 Protects Against Bone Loss in Women
description: Vitamin K2, a cofactor in the carboxylation of osteocalcin, is recognized as a protector against bone loss and fractures in postmenopausal women. Functionally, the availability of vitamin K regulates the carboxylation of osteocalcin.
---

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# [Vitamin K2 Protects Against Bone Loss in Women](https://info.bioticsresearch.com/researchforum/vitamin-k2-protects-against-bone-loss-in-women)

 Written by [The Biotics Research Team](https://info.bioticsresearch.com/researchforum/author/the-biotics-research-team) | Apr 26, 2018 2:31:00 PM

Vitamin K2, a cofactor in the carboxylation of osteocalcin, is recognized as a protector against bone loss and fractures in postmenopausal women. Functionally, the availability of vitamin K regulates the carboxylation of osteocalcin. “Epidemiological studies have found associations between serum undercarboxylated osteocalcin (ucOC) and the risk of hip fracture in elderly women[[1]](https://info.bioticsresearch.com/researchforum/vitamin-k2-protects-against-bone-loss-in-women?hs_amp=true#_ftn1) and between low intake of vitamin K1 and risk of hip fracture in older men and women.[[2]](https://info.bioticsresearch.com/researchforum/vitamin-k2-protects-against-bone-loss-in-women?hs_amp=true#_ftn2)” In this randomized, placebo-controlled, double-blinded clinical trial, supplementation with Vitamin K2 as MK-7 at a dose of 375ug or placebo for 12 months was evaluated for its benefits on bone mineral density. This was evaluated by “dual X-ray absorptiometry (DXA), bone microarchitecture, measured by high-resolution peripheral quantitative computed tomography (HRpQCT), and [additional] biochemical bone turnover markers, in 148 postmenopausal women with osteopenia.” 

All patients were also supplemented with calcium (800mg) and vitamin D (38µg). The change in undercarboxylated osteocalcin (ucOC) was determined as the primary endpoint. Following “6 months, the changes were -72.3% (-77.0; -66.6%) in the MK-7 group and -8.0 (-15.3; -0.1%) in the placebo group (P<0.01). Following 12 months the changes were -70.3 (-63.8; -75.6%) in the MK-7 group and -7.2 (-15.9; 2.0%) in the placebo group (*P*<0.01).” 

Changes in total osteocalcin also differed between the two groups. “Following 12 months the changes were -18.8 ± 13.9% in the MK-7 group and -2.5 ± 12.8% in the placebo group (*P* < 0.01).”

Thus, it was concluded that “treatment with MK-7, 365ug daily, in addition to calcium and vitamin D, for 12 months reduced serum levels of undercarboxylated osteocalcin by more than 70%, reduced the ratio ucOC/OC by more than 60%, increased bone-specific alkaline phosphatase (BAP) by 5%, and maintained microarchitecture in trabecular bone in tibia, despite no significant effects on BMD.” 

 

Ref.:  Ronn SH, Harslof T, Pedersen SB, Langdahl BL.   Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women. European Journal of Endocrinology. (2016) 175(6):541–549. 

[[1]](https://info.bioticsresearch.com/researchforum/vitamin-k2-protects-against-bone-loss-in-women?hs_amp=true#_ftnref1) Szulc P, Chapuy MC, Meunier PJ & Delmas PD. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. *J Clinical Investigation*. 1993 91 1769–1774. (doi:10.1172/JCI116387)

[[2]](https://info.bioticsresearch.com/researchforum/vitamin-k2-protects-against-bone-loss-in-women?hs_amp=true#_ftnref2) Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, Wilson PW, Ordovas J, Schaefer EJ, Dawson-Hughes B et al. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. *Am J Clin Nutr*. 2000 71 1201–1208.

 

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