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For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
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November 21 2024
The protective association between dietary flavonoid intake and the risk of dementia has been the focus of yet another study; this one being published...
Researchers investigated the association between serum folate levels and amyloid imaging to clarify whether serum folate could be a biomarker for Alzheimer’s disease (AD). They examined the usefulness of a combined assessment of serum folate levels and red blood cell hemoglobin content. Apolipoprotein E (APOE) gene polymorphisms were also assessed. “Serum folate levels and hemoglobin content were evaluated by receiver operation characteristic analysis for their diagnostic capability as AD biomarkers relating to brain amyloid β accumulation.” A high probability of also testing positive for amyloid was correlated to folate deficiency with low folate levels or non-anemia with high hemoglobin content. Of the 17 patients tested, eight were found to be folate deficient and non-anemia. Of these eight, seven were determined to be amyloid positive (87.5%), with only one amyloid negative (12.5%). Results suggest that a deficiency of serum folate and high hemoglobin levels may reflect an increased risk of amyloid β accumulation in the brain, and that the combination of serum folate levels and hemoglobin content is a more specific and sensitive blood biomarker for AD than APOE or folate alone. Consequently, these findings may be used to support clinical diagnosis of AD using a simple blood test.
Yoshinaga T, Nishimata H, Kajiya Y, Yokoyama S. Combined assessment of serum folate and hemoglobin as biomarkers of brain amyloid β accumulation. PLoS ONE. 12(4): e0175854. Pub April 13, 2017.
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