---
title: Folate and Hemoglobin – Biomarkers for Alzheimer’s Disease
description: Folate and Hemoglobin – Biomarkers for Alzheimer’s Disease
---

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# [Folate and Hemoglobin – Biomarkers for Alzheimer’s Disease](https://info.bioticsresearch.com/researchforum/2017/08/05/folate-and-hemoglobin-biomarkers-for-alzheimers-disease)

 Written by [admin](https://info.bioticsresearch.com/researchforum/author/admin) | Aug 5, 2017 3:33:29 PM

Researchers investigated the association between serum folate levels and amyloid imaging to clarify whether serum folate could be a biomarker for Alzheimer’s disease (AD). They examined the usefulness of a combined assessment of serum folate levels and red blood cell hemoglobin content. Apolipoprotein E (APOE) gene polymorphisms were also assessed. “Serum folate levels and hemoglobin content were evaluated by receiver operation characteristic analysis for their diagnostic capability as AD biomarkers relating to brain amyloid β accumulation.” A high probability of also testing positive for amyloid was correlated to folate deficiency with low folate levels or non-anemia with high hemoglobin content. Of the 17 patients tested, eight were found to be folate deficient and non-anemia. Of these eight, seven were determined to be amyloid positive (87.5%), with only one amyloid negative (12.5%). Results suggest that a deficiency of serum folate and high hemoglobin levels may reflect an increased risk of amyloid β accumulation in the brain, and that the combination of serum folate levels and hemoglobin content is a more specific and sensitive blood biomarker for AD than APOE or folate alone. Consequently, these findings may be used to support clinical diagnosis of AD using a simple blood test.

Yoshinaga T, Nishimata H, Kajiya Y, Yokoyama S. Combined assessment of serum folate and hemoglobin as biomarkers of brain amyloid β accumulation. PLoS ONE. 12(4): e0175854. Pub April 13, 2017.

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