---
title: AMPK and Metabolic Health
description: AMPK is a highly conserved sensor of adenosine nucleotide levels. Basically, it monitors energy, and is activated when ATP production decreases.
---

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# [AMPK and Metabolic Health](https://info.bioticsresearch.com/researchforum/ampk-and-metabolic-health)

 Written by [The Biotics Research Team](https://info.bioticsresearch.com/researchforum/author/the-biotics-research-team) | Feb 10, 2020 5:05:52 PM

An apple a day keeps the doctor away, at least according to a new [study](https://www.ncbi.nlm.nih.gov/pubmed/31916584)  that shows apple polyphenols increase the activity of 5’ adenosine monophosphate-activated protein kinase (AMPK). Activation of AMPK may be a good way to lose weight, balance lipoproteins, and support healthy blood sugar.

AMPK is a highly conserved sensor of adenosine nucleotide levels. Basically, it monitors energy, and is activated when ATP production decreases. Because AMPK inhibits fatty acid synthesis and increases fatty acid catabolism, researchers are investigating it as a possible pathway for weight loss. AMPK also inhibits HMG Co-A reductase, which influences cholesterol synthesis. 

Exercise, of course, is one sure way to increase AMPK, according to [studies](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/). There are also phytochemicals that can increase AMPK, such as the polyphenol, berberine. [Studies](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107476/) have shown that berberine has been reported to support healthy glucose and lipid levels. Berberine also promotes glucose consumption independent of AMPK activation, according to [studies](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114874/). 

Green tea polyphenols can also increase phosphorylation of AMPK. One [study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658135/) suggests  the activation of AMPK as a potential mechanism by which green tea polyphenols regulate hepatic lipid metabolism in such a way that lipid synthesis is reduced and fat oxidation is stimulated.

 

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