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eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
Biotics Research is proud to expand our commitment to education with the Wellness Unfiltered Pro Podcast. Each episode delves into key health topics and the clinical applications of our premier products. Through candid, insightful conversations, our team offers practical guidance to keep you informed and empowered as a healthcare professional.
February 05 2026
The journal Medicine (Baltimore) recently published the results of a meta-analysis of randomized and controlled trials evaluating the effect of curcum...
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The journal Medicine (Baltimore) recently published the results of a meta-analysis of randomized and controlled trials evaluating the effect of curcumin on inflammatory markers and disease activity among people with rheumatoid arthritis. This meta-analysis included 7 trials, all fairly small, ranging from 24 to 90 participants each, for a total of 333. The majority of the trials were rated to have moderate to high methodological quality, and most had a low risk of bias.
Five studies reported the commonly used marker of disease activity, DAS28 (Disease Activity Score in 28 joints), demonstrating a pooled reduction (weighted mean difference (WMD) of –1.47) from curcumin compared to controls, a clinically meaningful improvement. The studies that examined the effects of curcumin on inflammatory markers also showed significant reductions compared to the control, including rheumatoid factor (WMD = –24.15), erythrocyte sedimentation rate (WMD = –31.26), and C-reactive protein (WMD = –0.93).
The studies included in this meta-analysis are small but encouraging, and similar to results reported in a recent umbrella review published in Frontiers in Pharmacology, which also cited reductions in DAS28, rheumatoid factor, VAS (visual analogue scale) pain, and swollen and tender joint counts among people with rheumatoid arthritis. As the authors of the meta-analysis point out, curcumin inhibits key inflammatory pathways such as nuclear factor-kappa B and Janus kinase/signal transducer and activator of transcription, providing plausible biological mechanisms for its benefits (reviewed here). Additionally, the seven included studies had variation in their dosing regimens and formulations, and it seems quite likely that, given curcumin’s poor bioavailability, forms of curcumin with higher bioavailability, given at sufficient doses, would be the most effective.
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