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For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
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November 29 2025
JAMA Dermatology has recently published the results of a retrospective cohort study evaluating the efficacy of supplementation with nicotinamide, vita...

The Lancet Gastroenterology & Hepatology recently published the results of a trial investigating how people with irritable bowel syndrome (IBS) who have self-perceived gluten sensitivity react to gluten, wheat, or sham challenges. This was a randomized and double-blind sham-controlled crossover design, in which participants who believed (prior to the study) that they’d experienced improvement on a gluten-free diet were assigned a random sequence of either receiving gluten, wheat, or sham (in various orders) for 1 week, with a 14 day washout followed by the next challenge, with each participant receiving all 3 possible substances. The food was provided as cereal bars, indistinguishable from each other. The primary outcome was a 50-point worsening in the IBS Symptom Severity Score (IBS-SSS); a total of 28 people completed all 3 challenge periods.
Twenty-nine percent of participants had a 50-point worsening in the IBS-SSS during the sham challenge, compared to 39% with the wheat challenge and 36% with the gluten challenge, but the results were not statistically significant from each other. Adverse events (none serious) were reported in over 90% of participants during each challenge, again not significantly different.
The authors concluded that in this subset of people with IBS, expectations play a major role in symptom generation, with gluten or wheat likely playing a lesser role. While this study highlights the possible importance of expectations, it also had a number of limitations, including a small sample size, a short challenge duration and washout period, and given the large percentage of people experiencing adverse effects even in the sham group, perhaps another aggravating substance that masked the benefit of a gluten-free challenge. For example, multiple other studies suggest that controlling for FODMAP intake is important in this population.
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