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For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
Biotics Research is proud to expand our commitment to education with the Wellness Unfiltered Pro Podcast. Each episode delves into key health topics and the clinical applications of our premier products. Through candid, insightful conversations, our team offers practical guidance to keep you informed and empowered as a healthcare professional.
November 29 2025
JAMA Dermatology has recently published the results of a retrospective cohort study evaluating the efficacy of supplementation with nicotinamide, vita...

The European Journal of Internal Medicine has just published the results of a randomized and controlled clinical trial evaluating the effect of L-arginine combined with liposomal vitamin C when given to people with chronic obstructive pulmonary disease (COPD). Previous research has suggested that L-arginine metabolism is disturbed among people with COPD, with less L-arginine available for nitric oxide synthase (NOS) activity (and less nitric oxide production), and more funneled into arginase or incorporated into proteins, generating multiple inhibitors of NOS, such as asymmetric dimethylarginine (ADMA). This decrease in nitric oxide availability underlies the endothelial dysfunction observed among people with COPD, contributing to an increase in reactive oxygen species, as well as symptoms such as reduced exercise performance and a worsening in disease severity.
One hundred fifty people were enrolled, with roughly half receiving 1.66 g L-arginine and 500 mg liposomal vitamin C, twice daily, vs a matching placebo for 4 weeks. The primary outcome of the study was the variation in the CRQ-SA (Chronic Respiratory Questionnaire self-administered) score, a measure of health-related quality of life, with multiple functional secondary outcomes. After 4 weeks, significant improvements were observed with the active supplement in CRQ-SA scores, especially the subdomain of dyspnea, and other assessments of patient-reported symptoms or other activities of daily living (London Chest Activity of Daily Living Scale, etc.). No significant changes in lung function or exercise performance were observed, but an improvement in dyspnea perception occurred independently. Men were more likely to benefit than women, as well as people with poorer CRQ scores at baseline. Notably, this same combination/dose of L-arginine and vitamin C was associated with improved symptoms in a survey of people with Long-COVID symptoms.
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