---
title: Melatonin – Not Just for Sleep
description: We understand melatonin helps with sleep, but in a recent analysis of eight randomized controlled trials, melatonin supplementation was found to improve blood lipid status. Using a meta-analysis approac
---

[Research Forum ](https://info.bioticsresearch.com/researchforum)

# [Melatonin – Not Just for Sleep](https://info.bioticsresearch.com/researchforum/melatonin-not-just-for-sleep)

 Written by [The Biotics Research Team](https://info.bioticsresearch.com/researchforum/author/the-biotics-research-team) | Apr 12, 2018 6:54:10 PM

We understand melatonin helps with sleep, but in a recent analysis of eight randomized controlled trials, melatonin supplementation was found to improve blood lipid status. Using a meta-analysis approach, a “significant association between melatonin supplementation and a reduction in triglycerides (WMD: −31.54 mg/dL, 95% CI: −50.71, −12.38, p = 0.001) and total cholesterol levels (WMD: −18.48 mg/dL, 95% CI: −35.33, −1.63, p = 0.032)” was observed. No significant effect on LDL-C (WMD: −2.37 mg/dL, 95% CI: −11.61, −6.86, p = 0.615) and HDL-C (WMD: 1.28 mg/dL, 95% CI: −0.66, 3.23, p = 0.197) was found. A sub-group analysis found “a significant decrease in triglycerides at doses ≥8 mg/d when trials last[ed] ≥8 weeks. 

In addition, “a significant decrease of total cholesterol was [also] found at doses ≥8 mg/d, and when total cholesterol baseline levels were ≥200 mg/dL.”  Overall, the results indicate that melatonin supplementation has notable effects on triglycerides and total cholesterol levels, and is more evident with “higher dose and longer duration, and also [with] a higher concentration of cholesterol levels.”  Further studies are required to determine the benefits of melatonin on lipid profile.

Ref.:  Mohammadi-Sartang M, Ghorbani M, Mazloom Z. Effects of melatonin supplementation on blood lipid concentrations: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr. 2017 Nov 16. pii: S0261-5614(17)31401-2. doi: 10.1016/j.clnu.2017.11.003. [Epub ahead of print]

 

**Related Biotics Research Product:  ,  **

[View full post](https://info.bioticsresearch.com/researchforum/melatonin-not-just-for-sleep)

```json
{
  "@context" : "http://schema.org",
  "@type" : "BlogPosting",
  "author" : {
    "@type" : "Person",
    "name" : "The Biotics Research Team"
  },
  "dateModified" : "2020-07-07T04:53:22.516Z",
  "datePublished" : "2018-04-12T18:54:10Z",
  "headline" : "Melatonin – Not Just for Sleep",
  "image" : {
    "@type" : "ImageObject",
    "height" : 1242,
    "url" : "https://f.hubspotusercontent10.net/hubfs/4004166/bioticresearch_blog_assets/Structural_model.jpg",
    "width" : 1954
  },
  "mainEntityOfPage" : "https://info.bioticsresearch.com/researchforum/melatonin-not-just-for-sleep",
  "publisher" : {
    "@type" : "Organization",
    "logo" : {
      "@type" : "ImageObject",
      "height" : 60,
      "url" : "/hs/hsstatic/content_shared_assets/static-1.4092/img/default-amp-logo.png",
      "width" : 60
    },
    "name" : "Research Forum"
  }
}
```