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eStoreRx™
Online Supplement Dispensary
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
Biotics Research is proud to expand our commitment to education with the Wellness Unfiltered Pro Podcast. Each episode delves into key health topics and the clinical applications of our premier products. Through candid, insightful conversations, our team offers practical guidance to keep you informed and empowered as a healthcare professional.
February 19 2026
The journal Sleep Medicine Reviews recently published the results of a systematic review and meta-analysis examining melatonin supplementation among c...
The journal Sleep Medicine Reviews recently published the results of a systematic review and meta-analysis examining melatonin supplementation among children with neuropsychiatric and neurodevelopmental conditions, specifically to assess the variables that may optimally influence sleep, including dose, timing, and duration of treatment. Twenty-one studies (which followed PRISMA guidelines) were included, with differences compared between placebo and melatonin supplementation among children with a variety of diagnoses, such as ADHD, autism spectrum disorder, and other conditions often complicated by impaired sleep.
Overall, melatonin significantly improved total sleep time, increased sleep efficiency, and reduced sleep onset latency (the time it takes to fall asleep initially), but did not significantly improve wake after sleep onset (time spent awake after falling asleep). The optimal dose of melatonin was found to be between 2 and 4 mg, with the optimal timing found to be melatonin given 3 hours before bedtime. Also, a longer duration of melatonin supplementation was associated with increased total sleep time and sleep efficiency, suggesting more than just short-term gains.
These findings parallel results of a systematic review and meta-analysis of 26 randomized and controlled trials published in 2024, which included healthy adults and those with insomnia. In contrast to the often-recommended dosing of “1/2 an hour before bedtime,” this meta-analysis also found that the optimal timing is more likely to be 3 hours before bedtime. They also found that instead of the most frequently observed dose of 2 mg in clinical practice, increasing the dose up to 4 mg was associated with the largest improvements in promoting sleep.
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