Mounting evidence supports a protective effect of high 25(OH)D, an indicator of vitamin D status, on risk of various cancers including lung cancer. Researchers carried out a dose-response meta-analysis to elucidate the 25(OH)D – lung cancer association. Eligible studies were identified by searching PubMed and EMBASE databases, and the summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random-effects model. Thirteen reports from ten prospective studies were included, totaling 2,227 lung cancer events. Results of the meta-analysis showed a significant reduction in the risk of lung cancer for each 10 nmol/L increment in 25(OH)D concentrations. There was evidence of a nonlinear relationship between 24(OH)D and risk of lung cancer, with the greatest reductions in risk observed at 53 nmol/L, and remained protective until approximately 90 nmol/L. Higher levels showed no further significant association with cancer risk.
Guo-Chong Chen, et al. Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose-response meta-analysis. Cancer Causes & Control Sept 2015. Doi:10.1007/s10552-015-0665-6