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    Medicinal Properties of Curcumin

    Curcumin_herbal-supplement

    Curcumin has demonstrated several medicinal properties, including possessing an inhibitory effect on the virulence, quorum sensing (QS), and biofilm initiation.(1) Curcumin has also exhibited an inhibitory effect on the QS system of numerous pathogens, including E. coli and P. aeruginosa. This study examined the liposomes of curcumin as an inhibitory mechanism on QS system of Aeromonas sobria (AS), which “is a Gram-negative, rod-shaped, facultative anaerobic, motile, and flagellated bacterium,” that typically flourishes in various types of waters, as well as in soil and food. It is also “an opportunistic pathogen for animals and humans, [as] it can cause extra-intestinal infections and gastrointestinal diseases.”(2) In bacteria, a cell to cell communication mechanism called “Quorum sensing” allows the bacteria to monitor their population density by secreting signaling molecules or autoinducers.(3) These chemical signals are released from bacteria and accumulate in the environment. Once a threshold concentration is reached, the bacteria can bind to receptor proteins and trigger the expression of a series of QS targeting genes.(4) “Blocking the bacterial QS system has been considered as an alternative of traditional antibiotics.” Indeed, “many natural products and synthetic materials have been [demonstrated] to be quorum sensing inhibitors (QSIs). In this study the QS-controlled swimming and swarming motility of A. sobria was significantly inhibited by curcumin, as both liposome and free curcumin forms. Additionally, curcumin liposomes were demonstrated to be more effective than free curcumin in inhibiting swimming and swarming motility of A. sobria. Inhibition of biofilm formation was demonstrated up to 93.35% when compared to control (p < 0.05). The results also suggested that curcumin, “although having an effect on the on the biofilm formation, did not interfere with normal growth of bacteria.”

    Ting Ding T, Li T, Zhi Wang Z, Jianrong Li J. Curcumin liposomes interfere with quorum sensing system of Aeromonas sobria and in silico analysis. Scientific Reports. Published online: 17 August 2017.
    DOI:10.1038/s41598-017-08986-9.
    1. Rudrappa T, Bais HP. Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models. J. Agric. Food
    Chem. 2008 Mar 26;56(6):1955-62.
    2. Chang, H., Hung, Y. S., Shie, S. S. & Lin, T. L. Fulminant necrotizing fasciitis caused by Aeromonas sobria in neutropenic patients. Intern Med. 2012 51,3287–3290.
    3. Bucio-Cano, A. et al. Targeting quorum sensing by designing azoline derivatives to inhibit the N-hexanoyl homoserine lactonereceptor CviR: Synthesis as well as biological and theoretical evaluations.
    Bioorg Med Chem. 2015 23:7565–7577.
    4. Boyle KE, Monaco H, van Ditmarsch D, Deforet M, Xavier JB. Integration of Metabolic and Quorum Sensing Signals Governing the Decision to Cooperate in a Bacterial Social Trait. PLoS Computational
    Biol. 2015 11, e1004279.

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