Receive updates about our latest products in your inbox

Register For Our Next Webinar

Key Clinical Insights for Patients with Hypersensitive GI

About Us

For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional

Search the Blog

    DHA & Folic Acid

    iStock-1294349267In a recent randomized and double-blinded placebo-controlled clinical trial, the effects of folic acid, DHA, and their combined use were evaluated among 160 older adults with mild cognitive impairment. Plasma levels of amyloid-β (Aβ) peptide biomarkers as well as cognitive function were assessed at 6 months, after which all interventions were discontinued, and cognitive function tests were repeated at 12 months.

    Participants were given either 0.8 mg folic acid or 800mg DHA per day, placebo, or both supplements, and a revised version of the Wechsler Adult Intelligence Scale (WAIS-RC) was used to assess cognitive function. Several components of the WAIS-RC improved with both nutrients when used alone compared to placebo (e.g., full-scale intelligence quotient), while their combined use showed the largest improvements in several parameters (including arithmetic, block design, and picture arrangement), suggesting complementary action. Additionally, improvements in one-carbon metabolism (e.g., S-adenosylmethionine and homocysteine), as well as reductions in Aβ42 and Aβ40 (which increased in the placebo group) suggest possible further protection against dementia risk.

    The cognitive assessment done at 12 months, however, found essentially a return to baseline, suggesting that longer term supplementation may be necessary to achieve the outcomes observed after 6 months. This study provides additional evidence for the role of omega-3 fatty acids and folate in maintaining healthy cognitive aging, and lends support to a previous retrospective analysis which found B vitamins prevented brain atrophy only in participants with high omega-3 fatty acid levels.

    Submit your comment

    Related Post

    Study Shows DHA Levels Affect Quality Sleep

    Several studies in both animals and humans have found a bidirectional relationship between long-chain fatty acid levels ...

    Learn more

    A Recent Study Highlights Importance of DHA in Lung Health

    Acute respiratory distress syndrome (ARDS) is a form of acute diffuse lung injury characterized by inflammation leading ...

    Learn more


    A suboptimal diet has been ranked as the leading risk factor for total global deaths and the second-leading risk factor ...

    Learn more