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eStoreRx™
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eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
Biotics Research is proud to expand our commitment to education with the Wellness Unfiltered Pro Podcast. Each episode delves into key health topics and the clinical applications of our premier products. Through candid, insightful conversations, our team offers practical guidance to keep you informed and empowered as a healthcare professional.
March 27 2025
BMC Medicine recently published a post hoc analysis of the ADVANCE trial, describing the relationship between healthy lifestyle factors (HLF) and the ...
Results of a 1 year randomized and double-blind controlled clinical trial were recently published in Nutrients, describing the effectiveness of a specific form of vitamin K2, menaquinone-7 (MK-7), on vascular stiffness and blood pressure among postmenopausal women. Two-hundred forty-three participants were enrolled, both men and women, but a post-hoc analysis was conducted to specifically compare differences between pre/perimenopausal women (78) and post-menopausal women (87).
Additionally, all women included in the analysis were selected for poor vitamin K status, indicated by plasma desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) levels greater than 400 pmol/L. Decreased carboxylation of vitamin K-dependent enzymes has been linked to several chronic diseases, including cardiovascular disease, hypertension, and osteoporosis. For 1 year, participants received 180 µg of MK-7 per day or a placebo. Several assessments of vascular health were performed at baseline and after 1 year, including regional carotid-femoral (cf-PWV) and carotid-radial (cr-PWV) pulse wave velocities and an ultrasound examination of the carotid artery (intima–media thickness, stiffness, etc.).
After 1 year, MK-7 supplementation was associated with a reduction in dp-ucMGP among all women compared to placebo. Menopause was associated with an adverse effect on vascular health, marked by a significant increase in vascular stiffness, blood pressure, intima–media thickness, etc. The increase in arterial stiffness was attenuated with MK-7 supplementation (+9.4% vs. +49.1% with placebo), with the greatest effect observed among women with a high stiffness index. These women also had a significant reduction in blood pressure and an increased distensibility coefficient (arterial ability to contract/expand) with supplementation (both worsened with placebo). Overall, this study suggests that arterial health is adversely impacted by menopausal status, and that MK-7 supplementation may mitigate the decline in arterial health, especially among women with low vitamin K status.
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