Subscribe

Receive updates about our latest products in your inbox

Register For Our Next Webinar

Endocrine Disruptor Detox: Evidence-Based Approaches for Patient Health

About Us

For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional

Search the Blog

  • There are no suggestions because the search field is empty.

Micronutrient Cocktail & Liver Health

iStock-1483000268The journal Medicina recently reported the results of a double-blind and placebo-controlled pilot clinical trial evaluating the use of a micronutrient cocktail on parameters associated with liver fibrosis and steatosis among people with obesity and metabolic syndrome. One hundred ninety-six adults (median age 58) with obesity (BMI of 30 kg/m2 or higher, and an elevated abdominal circumference (AC)) and dyslipidemia were recruited, and randomized to receive either placebo or a daily dose of micronutrients, specifically 800 mcg 5-MTHF (5-methyltetrahydrofolate), 2g betaine, 1g ALA (alpha-linolenic acid), 700 mg EPA (eicosapentaenoic acid), 500 mg choline bitartrate, 280 mg DHA (docosahexaenoic acid), and 1000 mcg vitamin B12.

One hundred fifty-five participants completed the 3-month trial which monitored changes in 6 outcomes, including BMI, AC, cholesterol and triglyceride levels, controlled attenuation parameter (CAP), and transient elastography (TE), the latter 2 outcomes assessed by FibroScan technology, providing a measure of liver fat content (steatosis) and liver stiffness (fibrosis), respectively. One significant limitation of this study was the low rate of FibroScan evaluation; while offered at baseline and at 3 months, only 39 participants received both scans.

Despite the low rate of FibroScan completion, those participants receiving micronutrient supplementation had a significant reduction in CAP compared to placebo, a decrease of 4% compared to an increase of 5.4%. A similar improvement in the percent change in TE was also observed, a significant drop of 7.8% with micronutrient supplementation vs. an 8.6% increase with placebo. No other significant changes were observed. While limited by size and completion rate, this study suggests that providing omega-3 fatty acids, methyl donors, and vitamin b12 may improve objective signs of metabolic dysfunction-associated steatotic liver disease (MASLD) in adults with obesity and metabolic syndrome.

Submit your comment

Related Post

Celebrate with Nutrient-Rich Summer Foods

As we celebrate the 4th of July, it’s the perfect time to enjoy the bounty of nutritious summer foods. A plethora of res...

Learn more

Nutrient Support for PCOS

A systematic review and network analysis was recently published in PeerJ, evaluating the randomized clinical trials of v...

Learn more