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For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
Biotics Research is proud to expand our commitment to education with the Wellness Unfiltered Pro Podcast. Each episode delves into key health topics and the clinical applications of our premier products. Through candid, insightful conversations, our team offers practical guidance to keep you informed and empowered as a healthcare professional.
December 04 2024
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The journal Medicina recently reported the results of a double-blind and placebo-controlled pilot clinical trial evaluating the use of a micronutrient cocktail on parameters associated with liver fibrosis and steatosis among people with obesity and metabolic syndrome. One hundred ninety-six adults (median age 58) with obesity (BMI of 30 kg/m2 or higher, and an elevated abdominal circumference (AC)) and dyslipidemia were recruited and randomized to receive either placebo or a daily dose of micronutrients, specifically 800 mcg 5-MTHF (5-methyltetrahydrofolate), 2g betaine, 1g ALA (alpha-linolenic acid), 700 mg EPA (eicosapentaenoic acid), 500 mg choline bitartrate, 280 mg DHA (docosahexaenoic acid), and 1000 mcg vitamin B12.
One hundred fifty-five participants completed the 3-month trial which monitored changes in 6 outcomes, including BMI, AC, cholesterol and triglyceride levels, controlled attenuation parameter (CAP), and transient elastography (TE), the latter 2 outcomes assessed by FibroScan technology, providing a measure of liver fat content (steatosis) and liver stiffness (fibrosis), respectively. One significant limitation of this study was the low rate of FibroScan evaluation; while offered at baseline and at 3 months, only 39 participants received both scans.
Despite the low rate of FibroScan completion, those participants receiving micronutrient supplementation had a significant reduction in CAP compared to placebo, a decrease of 4% compared to an increase of 5.4%. A similar improvement in the percent change in TE was also observed, a significant drop of 7.8% with micronutrient supplementation vs. an 8.6% increase with placebo. No other significant changes were observed. While limited by size and completion rate, this study suggests that providing omega-3 fatty acids, methyl donors, and vitamin b12 may improve objective signs of metabolic dysfunction-associated steatotic liver disease (MASLD) in adults with obesity and metabolic syndrome.
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