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A recent study published in the journal Nature has elucidated the etiological basis of nausea and vomiting in pregnancy, commonly referred to as "morning sickness," and its more severe form, hyperemesis gravidarum (HG). The multinational research, involving the University of Southern California, University of Cambridge, and Sri Lankan researchers, identifies the hormone GDF15, produced by the fetus in the placenta, as a key factor in these conditions.
Nausea and vomiting affect approximately 70% of pregnant women, while HG, characterized by extreme symptoms leading to weight loss, dehydration, and potential hospitalization, affects about 2%. HG also elevates the risk of serious pregnancy complications such as pre-eclampsia and preterm birth. The study emphasizes the often-underdiagnosed nature of HG and its significant health implications.
The study's pivotal discovery is the variable sensitivity to GDF15 among individuals. It was observed that those with lower pre-pregnancy levels of GDF15 exhibited increased sensitivity during pregnancy. Conversely, individuals with high pre-pregnancy levels due to beta thalassemia, a genetic blood disorder, showed reduced sensitivity to the hormone during pregnancy. This variation in hormonal sensitivity elucidates the differential manifestation of morning sickness symptoms.
The research methodology encompassed a multifaceted approach. It involved analyzing GDF15 levels in the blood of pregnant individuals, genetic data assessment, and laboratory experiments on mice and human cells. These analyses led to the identification of potential intervention strategies for GDF15 sensitivity. One such strategy is pre-pregnancy exposure to increasing levels of GDF15, as suggested by an experiment in mice. Another proposed intervention is the administration of an antibody treatment targeting GDF15 or its receptors.
Marlena Fejzo, Ph.D., a clinical assistant professor at the University of Southern California Keck School of Medicine, highlighted the study's implications, stating compelling evidence supporting these methods in preventing or treating HG. Fejzo, who has personally experienced severe HG symptoms, underscored the significance of these findings in advancing the understanding and management of this condition.
This study represents a significant advancement in understanding the pathophysiology of morning sickness and HG, offering new avenues for prevention and treatment. It underscores the critical role of hormonal factors in pregnancy-related conditions and paves the way for more targeted therapeutic approaches.
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