Receive updates about our latest products in your inbox

Register For Our Next Webinar

A Holistic Practice Model for Management of Bloating and SIBO

About Us

For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional

Search the Blog

  • There are no suggestions because the search field is empty.

Omega-3s & Blood Pressure

iStock-1198469623A meta-analysis describing the dosing relationship between omega-3 fatty acid supplementation and blood pressure was recently published in the Journal of the American Heart Association. A systematic literature search yielded 71 eligible randomized controlled trials included in the analysis, with an overall sample size of nearly 5,000 participants aged 22 to 86. Seventy-nine percent of these trials were done in participants without hypertension or hyperlipidemia, with an average duration of 10 weeks. Most studies were conducted using fish or algae oil, though a small number used a dietary fish intervention. Additionally, roughly 75% of the studies used EPA and DHA at an average combined dose of 2.8 g per day.

This meta-analysis found a non-linear dose-response relationship between omega-3s and both systolic and diastolic blood pressure. In the overall analysis, a J-shaped curve was found, and a dose of 2-3 g EPA/DHA per day was associated with the greatest reduction in blood pressure. However, a subgroup analysis of only participants with a systolic blood pressure greater than 130mmHg found an approximately linear trend between blood pressure and dosage, with similar findings for those with hyperlipidemia. Overall this suggests that exceeding 2-3 g per day may have no additional benefit in patients without hypertension or hyperlipidemia, but in patients with either of those conditions, a higher dose may be associated with greater benefit.

Submit your comment

Related Post

Omega-3s & Blood Pressure

A dose-response meta-analysis of randomized controlled trials on omega-3 polyunsaturated fatty acids (PUFAs) and blood p...

Learn more