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eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
Biotics Research is proud to expand our commitment to education with the Wellness Unfiltered Pro Podcast. Each episode delves into key health topics and the clinical applications of our premier products. Through candid, insightful conversations, our team offers practical guidance to keep you informed and empowered as a healthcare professional.
January 23 2025
Environmental Science and Technology Letters recently published an analysis of the per- and polyfluoroalkyl substances (PFAS) content of 22 different ...
The journal Alzheimer’s & Dementia recently published results suggesting that urolithin A may have potential benefit for reducing degeneration as a consequence of Alzheimer’s disease (AD) through multiple mechanisms, at least in an animal model. This adds to a growing body of evidence that urolithin A has a critically important role in supporting mitochondrial function, especially the decline in function associated with neurodegeneration and aging, primarily by stimulating mitophagy, the removal of damaged mitochondria. This includes randomized and controlled trial data in humans indicating a boost in mitochondrial function, one that is associated with a number of benefits including increases in aerobic endurance and reductions in inflammation.
Urolithin A is a metabolite of ellagitannins (found in pomegranates, berries, walnuts, etc.) that is produced by the gut microbiota. This most recent study found that long-term use of urolithin A improved learning, memory, and olfaction in transgenic mice (an AD mouse model), and reduced biomarkers of disease pathology, including amyloid beta and tau pathologies. Multiple mechanisms of action were suggested by this study, but perhaps the most prominent was the stimulation of lysosomal function by regulating cathepsin Z (Ctsz) protein. Lysosomes are recyclers of dysfunctional cells (& mitochondria), with multiple functions related to cellular homeostasis. Cathepsins appear to be generally upregulated in brains affected by neurodegenerative diseases such as AD and Huntington’s disease but were normalized by urolithin A in this study. Urolithin A also had other effects associated with mitochondrial function, including an upregulation of sirtuins (SIRT1 and SIRT3) and a reduction in neuroinflammation. No human data related to neurodegenerative disease yet exists, though doses of 500-1000 mg per day of urolithin A were associated with exercise improvements in the controlled trial mentioned above.
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Alzheimer’s disease, Parkinson’s disease and other neurodegenerative conditions are typically seen – and treated – as di...
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