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For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
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March 06 2025
A recent study published in Annals of Neurology suggests that optimal vitamin B12 thresholds in older adults may need to be re-evaluated, and that sub...
A recent study published in Annals of Neurology suggests that optimal vitamin B12 thresholds in older adults may need to be re-evaluated, and that subclinical deficiencies may be responsible for neurological deficits. Much has been published previously describing the poor sensitivity of serum B12 as a functional biomarker for vitamin B12 status, as well as the possibility of subclinical deficits that may be unrecognized.
This study enrolled 231 healthy volunteers from the Brain Aging Network for Cognitive Health (BrANCH) at the University of California, San Francisco Memory and Aging Center. Participants, at a mean age of 71, had serum B12 as well as other indicators of B12 status measured, including holo-transcobalamin (holo-TC) and holo-haptocorrin (holo-HC), biologically active and inactive forms of B12, respectively. Participants then underwent numerous tests related to neurological and cognitive function, including quantitative brain MRI analyses, markers of myelin integrity (multifocal visual evoked potentials, mfVEP), as well as neuronal and glial integrity.
There were many significant findings from this study; for one, lower levels of holo-TC were associated with greater white matter intensities (MRI), lower spatial processing speed, and a delay in VEP latency. The latter has been considered to be a non-invasive and sensitive marker for myelin integrity, suggesting that even at “normal” serum levels of vitamin B12 in a healthy population, there may be an impairment in neurological function, one that could potentially explain the observed lower processing speed. On the other hand, elevated levels of holo-HC correlated with serum levels of Tau, recognized as a biomarker of neurodegeneration, and the clinical relevance of this is unclear. It’s important to note that only holo-TC has a specific receptor for cellular uptake, which is why it is considered to be the biologically active form. Clinicians may consider adding more functional tests, such as holo-TC and/or methylmalonic acid to screen for subclinical B12 deficits, especially in older patients.
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