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The Truth About Collagen Supplementation

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Chondroitin and Glucosamine for Colorectal Cancer Prevention?

Human-colonRecent evidence suggests the long term use of chondroitin and glucosamine supplements may be linked to reduced risk of colorectal cancer (CRC). Researchers evaluated the association between the use of these compounds and the risk of CRC in two prospective cohorts; the Nurses’ Health Study and the Health Professionals Follow-up Study. Regular use of these supplements was first assessed in 2002 and were followed until 2010. 672 CRC cases occurred over that time. Cox proportional hazards regression was used to estimate relative risks (RRs) within each cohort, and results were pooled using a random effects meta analysis. Associations were comparable across cohorts, with a RR of 0.79 observed for any use of glucosamine and a RR of 0.77 observed for any use of chondroitin. Use of glucosamine in the absence of chondroitin was not associated with risk of CRC, whereas use of chondroitin and glucosamine was significantly associated with risk. The association was comparable for cancers of the colon and rectum. Results support a protective association between the use of chondroitin and glucosamine and risk of CRC.
Fuchs C, Giovannucci E; Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses’ Health Study and Health Professionals Follow-up Study. International Journal of Cancer (June 2016).

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