According to a study published in 2012, Migraines affect 12% of the US population. While the number of studies related to migraine pathophysiology have increased in recent years, the exact aetioloty is not well understood. Wishing to compare the levels of trace elements and heavy metals in patients with acute migraine and healthy controls, researchers conducted a prospective study comprising migraine patients and an equal number of healthy controls. International Headache Society classification was used for diagnosing migraine. Serum copper (Cu), zinc (Zn), lead (Pb), iron (Fe), cadmium (Cd), cobalt (Co), manganese (Mn) and magnesium (Mg) levels were measured and assessed. Among the case participants were 22 females and 3 males (mean age 36 yrs). Among controls there were 21 females and 4 males (mean age 42 yrs). Results showed serum levels of Cu, Mg and Zn were significantly lower in patients with acute migraines (AMA) compared to controls, while Cd , Fe, Mn and Pb levels were higher in AMA patients compared to controls. No significant difference was seen for Co between the two groups. Researchers concluded that lower Mg and Zn concentrations may be related to the frequency of migraine attacks, and their administration may reduce the frequency of such attacks. Also, trace elements and heavy metals may have a role in the genesis of considerable oxidative stress in AMA patients.
Gonullu H, et al. The levels of trace elements and heavy metals in patients with acute migraine headache. J Pak Med Asso 65: 694; 2015