Subscribe

Receive updates about our latest products in your inbox

Register For Our Next Webinar

Rewiring the Brain for Weight Loss

About Us

For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional

Search the Blog

  • There are no suggestions because the search field is empty.

Probiotics Provide General Health Benefits on Various Systemic and Gastrointestinal Disorders

breakfast-stapleGastric ulcer is one of the most common chronic gastrointestinal [ailments] characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long term use of non steroidal anti inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibitors and antibiotics are commonly used to treat gastric ulcer. However, in the last few decades, the accumulating evidence for resistance to antibiotics and the side effects of antibiotics and acid inhibitors have drawn attention to the possible use of probiotics in the prevention and treatment of gastric ulcer. Probiotics are live microorganisms that when administered in adequate amounts confer health benefits on the host. The experimental and clinical studies currently available indicate that probiotics are promising for future applications in the management of gastric ulcers. This review aims to provide an overview of the general health benefits of probiotics on various systemic and gastrointestinal disorders with a special focus on gastric ulcer and the involved cellular and molecular mechanisms: i) Protection of gastric mucosal barrier; ii) upregulation of prostaglandins, mucus, growth factors and anti inflammatory cytokines; iii) increased cell proliferation to apoptosis ratio; and iv) induction of angiogenesis. Notably, administration of the exogenous probiotic strain Lactobacillus accelerated ulcer healing. Finally, some of the available data on the possible use of probiotics in H. pylori eradication are discussed.

Khoder G, Al-menhali AA, Al-Yassir F, Karam SM. Potential role of probiotics in the management of gastric ulcer. Experimental and Therapeutic Medicine. 2016; 12(1):3-17. doi:10.3892/etm.2016.3293.

Share This: 
 

Submit your comment

Related Post