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For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
Biotics Research is proud to expand our commitment to education with the Wellness Unfiltered Pro Podcast. Each episode delves into key health topics and the clinical applications of our premier products. Through candid, insightful conversations, our team offers practical guidance to keep you informed and empowered as a healthcare professional.
November 21 2024
The protective association between dietary flavonoid intake and the risk of dementia has been the focus of yet another study; this one being published...
Osteoarthritis (OA), a chronic articular disease characterized by cartilage degradation and osteophyte formation, involves mechanical and hereditary factors. French researchers investigated pro inflammatory paracrine interactions between human primary chondrocytes and macrophages following interleukin 1-β (IL-1β) treatment, to evaluate the molecular mechanism responsible for the inhibitory effect of resveratrol. They found that the activation of NF-kB in chondrocytes by IL-1β induced IL-6 secretion, which will then activate STAT3 protein in macrophages. Also, STAT3 was able to positively regulate IL-6 secretion, as confirmed by the doubling level of IL-6 in the coculture compared to macrophage monoculture. Resveratrol showed a strong inhibitory effect on the pro inflammatory marker secretion. The decrease of IL-6 secretion is dependent on the NF-kB inhibition in the chondrocytes, and the reduction of the IL-6 level can limit STAT3 activation in the macrophages, leading to the interruption of the inflammatory amplification loop. Researchers concluded that these results increase our understanding of the anti-inflammatory actions of resveratrol and open new potential approaches to prevent and treat osteoarthritis.
Limagne, E, et al. Resveratrol Interferes with IL1-β-Induced Pro-Inflammatory Paracrine Interaction between Primary Chondrocytes and Macrophages. Nutrients 2016, 8,280; doi: 10.3390/nu8050280
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