Receive updates about our latest products in your inbox

Register For Our Next Webinar

Younger Longer - Receptor Functionality & Keeping Hormones Zen

About Us

For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional

Search the Blog

    Vitamin D for Prostate Cancer?

    Mens-healthAccumulating evidence suggests that chronic prostatic inflammation may lead to prostate cancer development. Growth differentiation factor-15 (GDF-15) is highly expressed in the prostate and has been associated with inflammation and tu¬morigenesis. Researchers, led by Dr. Lambert, examined the relationship between GDF-15 and prostatic inflammation by measuring GDF-15 expression via immunohistochemical staining (IHC) in human prostatectomy specimens containing inflammation. To provide insight into a potential suppressive role for GDF-15 in inflammation, activation of NFkappaB (NFkB) was measured in PC3 cells. Researchers determined that an inverse relationship between GDF-15 and inflammation demonstrate a novel expression pattern for GDF-15 in the human prostate and suppression of NFkB activity. The researchers found that vitamin D up-regulates the expression of the GDF-15 protein, thereby suppressing inflammation by inhibiting NFkB, which has been shown to contribute to tumor formation and growth. According to Lambert “when you take vitamin D and put it on prostate cancer cells, it inhibits their growth.” While it hadn’t been proven to be an anti-cancer agent, they “wanted to understand what genes vitamin D is turning on or off in prostate cancer to offer new targets(1), Interestingly, back in 2005, Alex Vasquez postulated that a triad of vitamin D deficiency, fatty acid imbalance, and overconsumption of sugars (refined carbohydrates) are triggers of NFkB, the activation of which results in the up-regulation of genes which encode for the production of inflamma¬tory cytokines (TNF-a, IL-1, IL-6) and proinflammatory enzymes (iNOS, COX-2) and LIPOX, with “the clinical consequences of the burgeoning epidemics of metabolic and inflammatory diseases.”(2)
    (1) Farzaneh-Far R, et al. Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients with Coronary Heart Disease. JAMA, 2010 Jan 20; 303(3): 250.
    (2) O’Callaghan N , et al. Telomere shortening in elderly people with mild cognitive impairment may be attenuated with omega-3 fatty acid supplementation: A randomized controlled pilot study. J. Nutrition. Published online ahead of print, doi: 10.1016/j.nut.2013.09.013

    Share This: 

    Submit your comment

    Related Post

    Ginkgo Biloba Extract Improves Both Cognitive and Neurological Functions Following Stroke

    Ginkgo biloba has a long history of use in China "as a traditional herb for memory, depression, tinnitus and confusion."...

    Learn more

    Ashwagandha is Beneficial in Alleviating Cognitive Dysfunction

    In the obese individual, cognitive disturbances, including problem solving, working memory, and neuro-muscular coordinat...

    Learn more

    Medicinal Properties of Curcumin

    Learn more