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Policosanol Supplementation for Enhanced HDL Functionality

Red_heartResearchers at Yeungnam University in South Korea investigated functional and structural changes in lipoproteins after consumption of policosanol. They analyzed serum parameters in young non-smokers (YN), young smokers (YS), and middle-aged subjects (MN) who consumed policosanol daily (10 mg/day) for 8 weeks. After 8 weeks, systolic blood pressure was significantly lowered from initial levels in the YS and MN groups. Moisture content of facial skin increased from initial levels in the YS and MN groups. Serum triglyceride (TG) levels decreased in the YN and MN groups. The percentage of high-density lipoproteins-cholesterol (HDL-C) in total cholesterol was elevated in all subjects after 8 weeks of policosanol supplementation. All groups showed a reduction in serum glucose and uric acid levels. Serum cholesteryl ester transfer protein (CETP) activity was significantly diminished from initial levels in the YN and MN groups. Oxidation of the low-density lipoprotein fraction was markedly reduced accompanied by decreased apolipoprotein B (apoB) fragmentation. In the HDL fraction, paraoxonase activity was elevated along with elevation of apoA-I and cholesterol contents. The size and number of HDL particle increased, and the YS group showed a 2-fold increase in particle size. Daily consumption of policosanol for 8 weeks resulted in lowered blood pressure, reduced serum TG level and CETP activity, and elevated HDL-C contents. Researchers concluded that these functional enhancements of HDL can prevent and/or attenuate aging-related diseases, hypertension, diabetes and coronary heart disease.

 

Jae-Yong Kim, et al. Consumption of policosanol enhances HDL functionality via CETP inhibition and reduces blood pressure and visceral fat in young and middle-aged subjects. Int J of Mol Med 39: 889-899, 2017. DOI: 10.3892/ijmm.2017.2907

 

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