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Easy direct-to-patient ordering & fulfilment for Lifelong Wellness, eStoreRx™ is offered as part of the WholePractice membership or as a stand-alone program.
For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
This inclusive membership contains all of the the tools you need to grow your business, including WholeLifeRx™, Nimativ®, WholeLifeQ™, eStoreRx™ and Practice Success Programs.
Easy direct-to-patient ordering & fulfilment for Lifelong Wellness, eStoreRx™ is offered as part of the WholePractice membership or as a stand-alone program.
September 12 2024
BMC Microbiology recently published a meta-analysis of metagenomic sequencing data from obese and non-obese participants in an effort to clarify contr...
BMC Microbiology recently published a meta-analysis of metagenomic sequencing data from obese and non-obese participants in an effort to clarify contradictory findings relating the gut microbiome to the risk for an elevated BMI. Seven studies were included in this meta-analysis, as well as 1351 stool metagenomic (shotgun) sequencing files from 862 participants (396 with obesity and 466 controls) in 5 different countries (China, Australia, Denmark, Spain, and Sweden), with both bacterial and viral sequence data included in the analysis.
Overall, obesity was associated with a significant reduction in bacteriome and virome diversity and richness, yet there was an increase in the richness of both virulence factors (VF) as well as antibiotic resistance genes (ARG) in the microbiome of people with obesity. It’s worth noting that an increase in VF richness has previously been observed among people with obesity, though adopting a high-fiber diet was shown to reduce VF abundance and its associated inflammation.
Although early studies pointed to an increase in the Firmicutes to Bacteroidetes (F/B) ratio among people with obesity, it is a finding has subsequently been called into question, and this meta-analysis also found this ratio was decreased rather than increased, and the authors suggest it should not be a reliable marker for obesity. Nine bacterial species were increased among people with obesity, including the first report of Eubacterium sp. CAG:274, as well as previously reported associations with Megamonas hypermegale, Ruminococcus gnavus, Allisonella histaminiformans, Collinsella stercoris and Collinsella intestinalis. Twenty-nine beneficial species were enriched among the control group, including Akkermansia muciniphila and Eubacterium eligens. A number of other findings emerged from this meta-analysis, including an upregulation of specific pathways in obesity, such as lipopolysaccharide (LPS) synthesis, as well as associations between the gut virome and obesity, though the functional role of many of the viral operational taxonomic units remain unknown.
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