Subscribe

Receive updates about our latest products in your inbox

Register For Our Next Webinar

Rewiring the Brain for Weight Loss

About Us

For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional

Search the Blog

  • There are no suggestions because the search field is empty.

Prebiotics & Cognitive Function

iStock-1513072392_editedResults of a randomized controlled trial performed to evaluate the effectiveness of a prebiotic supplement on both muscle function and cognition in a healthy older population were recently published in Nature Communications. To limit genetic confounding, this study was conducted among twins (monozygotic and dizygotic) and is known as the PRebiotic and PrOtein on Muscle in Older Twins (PROMOTe) trial. Researchers from King’s College London randomized one twin from each pair (aged 63-83 years, an average of 73) to receive placebo and the other twin to receive 7.5 g of a prebiotic (comprised of inulin, 3.375 g, and fructooligosaccharides 3.488 g) per day for 12 weeks. Additionally, all participants in both groups received 3.32 g of a branched-chain amino acid powder daily (containing l-leucine, 1.66 g, l-isoleucine, 0.83 g, and l-valine, 0.83 g), and were advised to perform resistance exercises (squats, calf raises, sit-to-stand, etc.) at least twice per week.

No effect of prebiotic supplementation on muscle function was observed, including on the primary outcome or chair rise time, as well as secondary outcomes including hand grip strength, Short Physical Performance Battery (SPPB), or self-reported physical activity. However, microbiome analyses indicate that the prebiotic did impact the composition of the gut microbiota; many differences were found between groups, perhaps most notably an increase in Actinobacteria, especially Bifidobacterium, with prebiotic vs. placebo.

Additionally, the prebiotic appeared to improve cognition compared to placebo, assessed using CANTAB (Cambridge neuropsychological test automated battery) cognitive tests. Perhaps most important was a reduction in the number of errors in the Paired Associates Learning test, a memory test identified as a possible marker for diseases such as Alzheimer’s. Though a larger and more specific clinical trial should confirm and expand on these findings, previous studies suggest a prebiotic-associated improvement in cognition is possible.

Submit your comment

Related Post

Vitamin B2 & Cognitive Health

Results of a cross-sectional study were recently published in the Journal of Translational Medicine, detailing the assoc...

Learn more

Hearing Aids & Cognitive Decline

The Lancet has just published the results of the first randomized and controlled trial evaluating the effect of hearing ...

Learn more

Sleep, Exercise & Cognitive Function

The results of a 10-year longitudinal study were recently published in The Lancet Healthy Longevity, detailing the assoc...

Learn more