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Easy direct-to-patient ordering & fulfilment for Lifelong Wellness, eStoreRx™ is offered as part of the WholePractice membership or as a stand-alone program.
November 14 2024
Exciting research is being done in the burgeoning field called Metabolic Psychiatry, which is dedicated to addressing the bioenergetic underpinnings o...
Vitamin D is probably most known for its association with bone health, but a recent study suggests higher levels of vitamin D in the bloodstream may have a protective role against colorectal malignancy. In this study, the people who had lower levels of vitamin D had a 31 percent higher risk of colorectal malignancy, and those with higher levels of circulating 25(OH)D had a 22 percent lower risk.
The study included 17 cohorts, comprised of 5706 colorectal cancer patients and 7107 control subjects, all with a wide range of circulating 25(OH)D levels. The varying vitamin D levels were categorized based on what is currently recommended by the Institute of Medicine (IOM), based on bone health.
“Compared with the lower range of sufficiency for bone health (50–<62.5 nmol/L), deficient 25(OH)D (<30 nmol/L) was associated with 31% higher colorectal cancer risk (RR = 1.31, 95% confidence interval [CI] = 1.05 to 1.62); 25(OH)D above sufficiency (75–<87.5 and 87.5–<100 nmol/L) was associated with 19% higher colorectal cancer risk (RR = 0.81, 95% CI = 0.67 to 0.99) and 27% (RR = 0.73, 95% CI = 0.59 to 0.91) lower risk, respectively. Associations were minimally affected when adjusting for body mass index, physical activity, or other risk factors.
In conclusion, for each 25 nmol/L increments of circulating 25(OH)D, colorectal cancer risk was decreased 19% in women (RR = 0.81, 95% CI = 0.75 to 0.87) and 7% in men (RR = 0.93, 95% CI = 0.86 to 1.00). It appears that the optimal 25(OH)D concentrations associated with reducing colorectal cancer risk would be 75-100 nmol/L, higher than what is currently recommended by IOM for bone health.
Ref.: McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M, Cook NR, Eliassen AH, Zeleniuch-Jacquotte A, Agnoli C, Albanes D, Barnett MJ, Buring JE, Campbell PT, Clendenen TV, Freedman ND, Gapstur SM, Giovannucci EL, Goodman GG, Haiman CA, Ho GYF, Horst RL, Hou T, Huang W-Y, Jenab M, Jones ME, Joshu CE, Krogh V, Lee I-M, Lee JE, Männistö S, Le Marchand L, Monduln AM, Neuhouser ML, Platz EA, Purdue MP, Riboli E, Robsahm TE, Rohan TE, Sasazuki S, Schoemaker MJ, Sieri S, Stampfer MJ, Swerdlow AJ, Thomson CA, Tretli S, Tsugane S, Ursin G, Visvanathan K, White KK, Wu K, Yaun S-S, Zhang X, Willett WC, Gail MH, Ziegler RG, Smith-Warner SA. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts. JNCI: Journal of the National Cancer Institute, djy087, https://doi.org/10.1093/jnci/djy087
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