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Easy direct-to-patient ordering & fulfilment for Lifelong Wellness, eStoreRx™ is offered as part of the WholePractice membership or as a stand-alone program.
April 18 2024
Results of a large population-based observational cohort study examining the association between weight loss and diabetes remission were recently publ...
Researchers from the University of Michigan have found that when fruit flies are put on a high sugar diet, key metabolites related to brain health become depleted.
A previous study performed in the same institution showed that an increase in the metabolite glucosamine-6-phosphate with a high sugar diet caused overeating and obesity in fruit flies.
These study findings could tell us when our behaviors such as food intake, learning and memory and sleep change on high-nutrient diets. Our bodies break down food into metabolites, which are small molecules that provide fuel to cells, activate or inhibit enzymes, and perform other functions. This study looked at how these metabolites changes in the brains and bodies of fruit flies as they transition between hunger and satiety.
The results of the study showed that the flies’ metabolic profiles change quickly as they move from hunger to satiety, and the biggest change occurs in their brains rather than their bodies. A high sugar diet lowered brain metabolite levels, including N-acetyl aspartate (NAA), and kynurenine levels. This could affect how quickly the fly feels satiety and making them eat more. By the seventh day on a high-sugar diet, the fruit flies had a completely altered metabolic profile. The sugar consumption affected the levels of 20 different metabolites in total during the study.
Scientists aren’t yet sure of the effect of NAA in the brain, but it appears to provide fuel for brain cells and regulate cell volume within the organ. Lower kynurenine levels are associated with depression.
Next, the researchers plan to focus on investigating how changes in the various metabolites impact the brain, food intake and how they affect other conditions such as sleep, learning, and memory.
A “Halloween hangover” could, in fact, have a scientific basis.
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