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For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
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April 10 2025
The results of a randomized and controlled dietary trial, including a multi-omics analysis of immune and metabolic changes associated with switching b...
The results of a randomized and controlled dietary trial, including a multi-omics analysis of immune and metabolic changes associated with switching between a Western-style dietary pattern and a Kilimanjaro heritage-style pattern, were recently published in Nature Medicine. Male non-overweight participants between the ages of 20 to 40 were recruited from one of two cohorts in Northern Tanzania. The first group of men was from a rural area and followed a traditional dietary pattern while the second group was from an urban area where a Western-style diet was more common, with a nutritionist ensuring these respective diets were adhered to prior to the intervention.
There were 3 arms in this open-label study in which 3 meals were provided each day. In the first, 22 men following the heritage-style diet switched to a Western-style diet for 2 weeks (with 5 controls maintaining their diets), in the second arm 22 men switched from the Western to the heritage diet (also with 5 controls), and in the 3rd arm, 22 men following a Western diet began consuming a traditional fermented banana-based beverage (Mbege) for 1 week (no controls).
Among the many outcomes documented in this short-term trial, switching to the largely plant-based heritage-style pattern (as well as the fermented beverage) produced anti-inflammatory effects, while the switch to a Western diet promoted a pro-inflammatory state, marked by changes in the plasma proteome and metabolome, cytokine production, and the whole blood transcriptome, with some changes persisting for 4 weeks following the switch. There were several limitations of the study; food was consumed ad libitum, and weight gain associated with the Western diet may have played a role in the generally unfavorable immunomodulatory effects observed. Despite this, the study provides additional support for this traditional dietary pattern, as well as highlighting the harms of a Western pattern.
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Research has shown that a healthy inflammatory response is an essential part of the body’s healing process. Yet ongoing ...
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