Shop
eStoreRx™
Online Supplement Dispensary
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
Biotics Research is proud to expand our commitment to education with the Wellness Unfiltered Pro Podcast. Each episode delves into key health topics and the clinical applications of our premier products. Through candid, insightful conversations, our team offers practical guidance to keep you informed and empowered as a healthcare professional.
November 21 2024
The protective association between dietary flavonoid intake and the risk of dementia has been the focus of yet another study; this one being published...
Berberine has become synonymous with supporting the maintenance of healthy blood sugar levels, as well as having benefits for the gut, brain and heart. A recent article delves into the biological mechanisms of this botanical to confirm its influence on blood sugar.
Although not fully understood, the pathogenesis of Type 2 Diabetes Mellitus (T2DM) seems to stem from both oxidative stress and inflammation. The inflammatory condition may be the result of various kinase and signaling pathways influencing adipocytes and immunocytes to produce interleukin-6 (IL-6) and tumor necrosis factor-α (TNF- α), both involved in the pathogenesis of T2DM. When the nuclear factor-kB (NF-κB) pathway is activated by these cytokines, it may disrupt the insulin signaling pathways and also induce dysfunction of the islets β-cells.
Berberine appears to act on these inflammatory pathways. Following the administration of berberine in diabetic animal studies, modified levels of proinflammatory cytokines and oxidative stress markers were observed. It was noted that “berberine acted against inflammation through a very complex mechanism consisting of several kinases and signaling pathways involving various factors, including NF-kB and AMP-activated protein kinases (AMPK).”
Although the precise mechanisms involved remain unclear, inflammation is considered a “crucial risk factor” for T2DM, and berberine may help support the inflammatory pathways.
This article also noted that berberine acts as an antioxidant, thereby inhibiting oxidative stress also associated with the development of insulin resistance. In hyperglycemic animals fed berberine, higher levels of glutathione (GSH), glutathione peroxidase (GSHPx), and superoxide dismutase (SOD) were noted as well as suppressed levels of malondialdehyde (MDA). The authors concluded that “berberine is involved in the regulation of GSH/GSHPx antioxidant system in diabetic patients, and that there exists an association between the antioxidant potential of berberine and its suppressive influence on developing T2DM and insulin resistance.”
By supporting healthy inflammatory pathways and acting as an antioxidant, berberine once again scores high points for blood sugar support.
Related Biotics Research Products: 
, 
Submit this form and you'll receive our latest news and updates.
JAMA Network Open recently published an analysis of several large cohorts of men and women, indicating a lower risk for ...
Learn moreGynecological Endocrinology recently published a systemic review and meta-analysis examining the relationship that glyce...
Learn moreResults of a large population-based observational cohort study examining the association between weight loss and diabete...
Learn more
*These statements have not been evaluated by the Food and Drug Administration. This product has not intended to diagnose, treat, cure, or prevent any disease.
© 2023 Biotics Research Corporation - All Rights Reserved
Submit your comment