Receive updates about our latest products in your inbox

Register For Our Next Webinar

Key Clinical Insights for Patients with Hypersensitive GI

About Us

For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional

Search the Blog

    High Fat Diet Alters Gut Physiology

    iStock-1133727579In a study just published in Science, a mouse-model of diet-induced obesity was used to elucidate possible mechanisms by which a high-fat diet can contribute to atherosclerosis. Animals fed a high-fat diet rich in choline had disruptions in mitochondrial bioenergetics in the cells lining the intestinal tract. The subsequent drop in ATP production, as well as an increase in oxygen and nitrate leakage from colonic epithelial cells, was a driver for changes in the microbiome; specifically, an increase in species such as E. coli that are better adapted to the oxygen-rich environment. Alterations in the microbiome, in turn, led to increased conversion of choline to trimethylamine (TMA), ultimately converted in the liver to trimethylamine-N-oxide (TMAO), well-known for being an independent risk factor for cardiovascular disease.

    This study adds to the growing evidence base for the role of diet-induced changes in the microbiome, and how they influence the risk for cardiovascular disease. It helps to broaden our understanding of the mechanisms involved, which include TMA production as well as other microbial metabolites such as short chain fatty acids and secondary bile acids. Indeed, the microbiome is gaining recognition as the chief interface between our cells and the environment, perhaps mediating many of the disease risks typically attributed to “environmental factors,” including hypercholesterolemia. It also helps to pinpoint how interventions, which modify the microbiome, including probiotics and other lifestyle factors, may have the potential to reduce cardiovascular risk.

    Submit your comment

    Related Post

    UTIs, Antibiotics & Gut Microbiome

    In a study recently published in Nature Microbiology, a longitudinal multi-omics analysis was reported for women with a ...

    Learn more

    The Importance of the Gut Microbiome During Pregnancy

    As more data emerges supporting the importance of the gut microbiome during pregnancy, the link between changes in the m...

    Learn more

    Poor Gut Health Linked to Lung Function

    A recent review has uncovered the relationship between lung function and poor gut health.

    Learn more