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Magnesium & Vitamin D Activation

iStock-953623576A compelling article in The Journal of the American Osteopathic Association highlighted the important role of magnesium in vitamin D activation and function.

The intestinal absorption and metabolism of nutrients often depend on the availability of other nutrients. Yet the supplementation of many nutrients, including magnesium and vitamin D, is usually provided separately.

An article from BMC Medicine provided a thorough overview of the relationship between magnesium and vitamin D and how magnesium could be used for the optimization of vitamin D status. After its discovery in 1913, vitamin D’s role in health was better understood. Vitamin D deficiency is a pressing health concern because it is considered an independent risk factor for mortality. Yet studies on rickets have shown that hypovitaminosis D-associated risk of mortality could be modified by the consumption of magnesium.

Magnesium assists in the activation of vitamin D, helping regulate calcium and phosphate homeostasis to ensure the growth and maintenance of bone. Every one of the enzymes that metabolize vitamin D seems to require magnesium, which acts as a cofactor in the enzymatic reactions in the kidneys and liver. The authors of the study urge that it is therefore crucial to ensure that the recommended amount of magnesium is brought into the body if all the optimum benefits of vitamin D intake is the goal.

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