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For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
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November 29 2025
JAMA Dermatology has recently published the results of a retrospective cohort study evaluating the efficacy of supplementation with nicotinamide, vita...

The results of a double-blind randomized and controlled clinical trial evaluating the effect of vitamin D supplementation on acute respiratory tract infections (ARTI) in children living in Northern latitudes were recently published in the European Journal of Nutrition. This was a secondary analysis of a controlled trial investigating vitamin D supplementation as well as varying levels of protein intake on children’s health and growth. Two-hundred healthy white children living in Denmark were included in this analysis, who received either 20 ug/day (800 IU/day) of vitamin D3 or a placebo for 24 weeks.
Baseline 25-OH vitamin D levels were just under 80 nmol/L (~29 ng/mL), a level often considered sufficient and surprising for a Northern latitude, suggesting vitamin D supplementation may have occurred prior to the study’s onset. Levels increased by 9.4 nmol/L among children receiving vitamin D, and decreased by 32.7 nmol/L with placebo. Notably, the study began in late summer/fall, when 25-OH vitamin D levels would be expected to peak before a drop during the winter. Using monthly self-reports from parents, vitamin D supplementation was associated with 17% fewer sick days due to ARTI, and 43% fewer days with ARTI with fever (when compared to placebo).
This falls on the heels of a meta-analysis recently published in The Lancet: Diabetes & Endocrinology, which found that a protective effect of vitamin D did not reach statistical significance. However, a stratified analysis of the studies included in the meta-analysis did find a significant protective effect when considering age, dose, and frequency of supplementation. For example, in trials in which participants were aged 1-15, or given daily vs. weekly/monthly supplements, or given doses between 400-800 IU (not less than 400 IU), a protective effect was observed.
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The American Journal of Clinical Nutrition recently published the results of a randomized and placebo-controlled trial e...
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