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For over 40 years, Biotics Research Corporation has revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. Combining nature’s principles with scientific ingenuity, our products magnify the nutritional
eStoreRx™ is an easy direct-to-patient ordering & fulfilment program for lifelong wellness.
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November 26 2024
Results of a study recently published in the European Journal of Nutrition suggest that low levels of magnesium may increase the susceptibility of DNA...
In Genome Medicine, Harvard researchers recently published their analysis of metagenomic profiling of the gastrointestinal microbiome of patients hospitalized with COVID-19 during the first year of the pandemic. Between April 2020 and May 2021, 127 consecutive hospitalized adult patients with confirmed COVID-19 (at Massachusetts General Hospital) were categorized as having either severe or moderate disease, the former requiring ICU admission for respiratory failure or other organ failures. Metagenomic sequencing of stool samples (as well as predicted, not measured, metabolite levels) were used to detect potential differences between people with severe vs. moderate disease.
The researchers reported both community and species level differences which could predict disease severity, and tested these predictions in an independent cohort of 38 patients, helping to verify the validity of their results. Their models indicated that patients with more severe disease had multiple differences, such as reduced microbial diversity, including the depletion of 46 species-level taxa. This included depletion of Fusicatenibacter saccharivorans and Roseburia hominis, the former previously found to have a positive association with VO2max in men, increased butyrate production and reduced inflammation; both species were previously associated (inversely) to greater risk for long COVID. Eight taxa had increased relative abundance in the tool (such as Methanobrevibacter smithii and Bilophila wadsworthia), and multiple metabolic pathways were predicted to be affected, including reduced amino acid biosynthesis and short-chain fatty acid (SCFA) production pathways, as well as enrichment of primary bile acids and reduction of secondary bile acid metabolites.
This is not the first study to suggest that the microbiome plays a role in susceptibility to both severe disease following SARS-CoV-2 infection as well as persistent symptoms following infection, and that the modulation of microbial metabolites (e.g., bile acids, SCFAs, etc.) may be an important determinant of outcomes.
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BMC Microbiology recently published a meta-analysis of metagenomic sequencing data from obese and non-obese participants...
Learn moreResults of a prospective and longitudinal study conducted among schoolchildren were recently published in Allergology In...
Learn moreResults of a small human clinical trial recently published in NPJ Biofilms and Microbiomes indicate that short-term use ...
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